Barrios Vivencio, Escobar Carlos, Calderón Alberto, Llisterri José Luis, Alegría Eduardo, Muñiz Javier, Matalí Arantxa
Instituto de Enfermedades del Corazón, Hospital Ramón y Cajal, Madrid, España.
Med Clin (Barc). 2007 May 5;128(17):647-51. doi: 10.1157/13102050.
The aim of this study was to know the treatment of hypertensive patients with metabolic syndrome (MetS) attended in primary care setting, as well as the blood pressure and LDL-cholesterol (LDL-c) rates, and to compare these data with those of the hypertensive population without MetS.
We analyzed the subset of patients with MetS from those included in the PRESCOT study (a cross-sectional study of hypertensive subjects >18 years attended in primary care). The PRESCOT population was composed by 12,954 patients (49.9% females; 62.1+/-10.7 years). MetS was diagnosed according to NCEP-ATP-III criteria.
6,736 (52%) patients fulfilled diagnosis criteria of MetS (mean age 62.3+/-10.5 years; 43.9% males). Almost all MetS patients (98.2%) were on any medication, and 80.5% were at least on two drugs. Despite hypertensive MetS patients were treated with more antihypertensive medications (45.3% vs 36.6% were on two or more drugs, p < 0.001) and used more lipid-lowering agents (43% vs 39.1%, p < 0.001) than patients without MetS, the blood pressure control (according to European guidelines) and LDL-c control (according to NCEP-ATP III) rates were lower in patients with MetS (17.2% vs 33.6% and 17.2% vs 35.7%, p < 0.0001). Only 4.7% of patients with MetS were adequately controlled for both factors, LDL-c and blood pressure, vs 13.5% of patients without MetS, (p < 0.0001).
The presence of MetS in the hypertensive population attended in Spanish primary care settings is very common. Even though in hypertensives with MetS more drugs are prescribed, blood pressure and LDL-c control rates are worse in this population than in patients without MetS.
本研究旨在了解在基层医疗环境中接受治疗的代谢综合征(MetS)高血压患者的治疗情况、血压和低密度脂蛋白胆固醇(LDL-c)水平,并将这些数据与无MetS的高血压人群的数据进行比较。
我们分析了PRESCOT研究(一项针对基层医疗中年龄大于等于18岁的高血压患者的横断面研究)中患有MetS的患者亚组。PRESCOT研究人群由12954名患者组成(女性占49.9%;年龄62.1±10.7岁)。根据NCEP-ATP-III标准诊断MetS。
6736名(52%)患者符合MetS诊断标准(平均年龄62.3±10.5岁;男性占43.9%)。几乎所有MetS患者(98.2%)都在服用某种药物,80.5%至少服用两种药物。尽管患有MetS的高血压患者比无MetS的患者使用了更多的抗高血压药物(45.3%对36.6%服用两种或更多药物,p<0.001)和更多的降脂药物(43%对39.1%,p<0.001),但根据欧洲指南,MetS患者的血压控制率和根据NCEP-ATP III的LDL-c控制率更低(分别为17.2%对33.6%和17.2%对35.7%,p<0.0001)。只有4.7%的MetS患者的LDL-c和血压这两个因素得到充分控制,而无MetS的患者为13.5%,(p<0.0001)。
在西班牙基层医疗环境中接受治疗的高血压人群中,MetS的存在非常普遍。尽管患有MetS的高血压患者使用了更多药物,但该人群的血压和LDL-c控制率比无MetS的患者更差。