The intestinal tract as the major source of interleukin 6 production during abdominal aortic clamping and hind limb ischaemia-reperfusion injury.
作者信息
Pimenta Márcio Benedito Palma, Aguilar-Nascimento José Eduardo de, Martins Dely Cristina, Silva Daniele Ribastski da, Bacelo Kátia Leston, Bocchese Isabel Cristina, Zaffani Sarai, Zaffani Elieser, Silveira Erika Alessandra Oliveira, Carmo Aracelle Victor do, Ferreira Simone Sampaio Saldanha
机构信息
Department of Surgery, Federal University of Mato Grosso, 78045-390 Cuiabá, MT, Brazil.
出版信息
Acta Cir Bras. 2007 Mar-Apr;22 Suppl 1:34-9. doi: 10.1590/s0102-86502007000700008.
PURPOSE
The aim of this study was to investigate whether the hind limbs or intestinal tract is the most important initiator of the inflammatory response secondary aortic clamping and hind limb ischemia/reperfusion injury.
METHODS
Blood samples of Wistar rats obtained from posterior cava vein, portal vein, and heart cavity during either laparotomy (control group, n=8) or laparotomy + 2 h of aortic clamping and bilateral hind limb ischemia (ischemia group, n=8), or 2 h after ischemia and 2 h of reperfusion (ischemia-reperfusion group, n=8) were assayed for interleukin 6 (IL-6) and C-reactive protein (CRP).
RESULTS
Serum IL-6 at the heart (223.6+/-197.9 [10-832] pg/mL) was higher (p<0.001) than at both portal (133.08+/-108.52 [4-372] pg/mL) and posterior cava veins (127.58+/-109.15 [8-388] pg/mL). CRP was not significant different among groups.
CONCLUSION
The splanchnic region is also a source of inflammatory response secondary to ischemia and reperfusion of the hind limbs.
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