Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.
Mol Med Rep. 2020 Oct;22(4):3225-3232. doi: 10.3892/mmr.2020.11429. Epub 2020 Aug 12.
Limb ischemia/reperfusion (I/R) can induce inflammation, causing acute lung injury. The Toll‑like receptor 4 (TLR4)/NF‑κB pathway plays an important role in acute and chronic inflammatory disorders. Several studies have demonstrated the efficacy of acupuncture in lung inflammatory injury. The aim of the present study was to elucidate the mechanism underlying the protective effect of electroacupuncture (EA) against lung injury induced by limb I/R. EA applied at the Zusanli and Sanyinjiao acupoints attenuated lung injury and decreased the secretion of inflammatory factors such as tumor necrosis factor‑α, interleukin (IL)‑1, IL‑6 and myeloperoxidase. Moreover, the expression levels of TLR4 and NF‑κB were suppressed by EA. Thus, the present findings suggested that EA can reduce pulmonary inflammation induced by limb I/R injury, possibly via the inhibition of the TLR4/NF‑κB pathway.
肢体缺血/再灌注（I/R）可引发炎症，导致急性肺损伤。Toll 样受体 4（TLR4）/NF-κB 通路在急性和慢性炎症性疾病中发挥重要作用。多项研究已经证实了针刺在肺炎症性损伤中的疗效。本研究旨在阐明电针对肢体 I/R 诱导的肺损伤的保护作用的机制。足三里和三阴交穴位的电针治疗可减轻肺损伤，并降低肿瘤坏死因子-α、白细胞介素-1（IL-1）、IL-6 和髓过氧化物酶等炎症因子的分泌。此外，电针还可抑制 TLR4 和 NF-κB 的表达水平。因此，本研究结果表明，电针可能通过抑制 TLR4/NF-κB 通路，减轻肢体 I/R 损伤引起的肺部炎症。
