Vila P, Vallès J, Canet J, Melero A, Vidal F
Department of Anaesthesiology, Hospital de Badalona, Germans Trias i Pujol, Barcelona, Spain.
Anaesthesia. 1991 Nov;46(11):967-9. doi: 10.1111/j.1365-2044.1991.tb09860.x.
Famotidine and ranitidine were compared as agents for the prevention of acid aspiration syndrome in 32 morbidly obese patients undergoing vertical banded gastroplasty. Single-dose oral famotidine or double-dose oral ranitidine were administered on a random basis before surgery. Gastric contents were aspirated through a gastric tube, manually aided by the surgeon with the abdomen open. Mean (SD) gastric volumes were 13.8 ml (6.7) and 12.1 ml (13.0) for the famotidine and ranitidine groups, respectively. Mean (SD) gastric pH values were 6.2 (1.5) and 6.8 (1.5), respectively. There were no significant differences between the groups and no patient was considered 'at risk' (pH less than 2.5 and gastric volume greater than 25 ml). We conclude that single-dose oral famotidine and double-dose oral ranitidine are equally effective for preventing acid aspiration syndrome in morbidly obese patients.
在32例接受垂直捆绑胃成形术的病态肥胖患者中，比较了法莫替丁和雷尼替丁预防胃酸误吸综合征的效果。术前随机给予单剂量口服法莫替丁或双剂量口服雷尼替丁。通过胃管抽吸胃内容物，外科医生在腹部打开的情况下手动辅助。法莫替丁组和雷尼替丁组的平均（标准差）胃容量分别为13.8 ml（6.7）和12.1 ml（13.0）。平均（标准差）胃pH值分别为6.2（1.5）和6.8（1.5）。两组之间无显著差异，且无患者被视为“高危”（pH值小于2.5且胃容量大于25 ml）。我们得出结论，单剂量口服法莫替丁和双剂量口服雷尼替丁在预防病态肥胖患者胃酸误吸综合征方面同样有效。
