Suppr超能文献

C反应蛋白浓度与晚年抑郁症之间的关联是由于身体健康状况不佳:男性健康研究(HIMS)的结果

The association between C-reactive protein concentration and depression in later life is due to poor physical health: results from the Health in Men Study (HIMS).

作者信息

Almeida Osvaldo P, Norman Paul, Hankey Graeme J, Jamrozik Konrad, Flicker Leon

机构信息

WA Centre for Health and Ageing, University of Western Australia, Australia.

出版信息

Psychol Med. 2007 Dec;37(12):1775-86. doi: 10.1017/S0033291707000827. Epub 2007 May 17.

Abstract

BACKGROUND

C-reactive protein (CRP) is a non-specific marker of inflammation that has been associated with depression and vascular disease, particularly in men. This study aimed to investigate the association between high CRP concentration and depression while taking physical health into account.

METHOD

A cross-sectional study of a community-dwelling sample of 5438 men aged 70+. Participants with scores > or =7 on the 15-item Geriatric Depression Scale (GDS-15) were considered to display clinically significant depressive symptoms. We measured the serum concentration of CRP with a high-sensitivity assay. The assessment of physical co-morbidity included three components: the Charlson weighted index, self-report of major health events on a standardized questionnaire, and the physical component of the 36-item Short-Form Health Survey (SF-36). Other measured factors included age, native language, education, a standardized socio-economic index, smoking, prior or current history of depression treatment, cognitive impairment (Mini-Mental State Examination score < 24 and body mass index (BMI).

RESULTS

Participants with depression(n=340) wereolder than their controls without depression (age in years: 76.6 +/- 4.4 v. 75.4+/- 4.1). Men with CRP concentration > 3 mg/l had an increased odds ratio (OR) [1.59, 95% confidence interval (CI) 1.20-2.11] of being depressed compared to men with CRP 3 mg/l. This association became non-significant once we adjusted the analysis for the measures of physical co-morbidity and other confounding factors (OR 1.22, 95% CI 0.86-1.73).

CONCLUSIONS

The physiological mechanisms that lead to the onset and maintenance of depressive symptoms in older men remain to be determined, but CRP concentration is unlikely to play a significant role in that process.

摘要

背景

C反应蛋白(CRP)是一种非特异性炎症标志物,与抑郁症及血管疾病有关,尤其是在男性中。本研究旨在探讨高CRP浓度与抑郁症之间的关联,同时考虑身体健康因素。

方法

对5438名70岁及以上社区居住男性样本进行横断面研究。15项老年抑郁量表(GDS-15)得分≥7分的参与者被认为有临床显著的抑郁症状。我们用高灵敏度检测法测量血清CRP浓度。身体共病评估包括三个部分:查尔森加权指数、标准化问卷上的重大健康事件自我报告以及36项简短健康调查(SF-36)的身体部分。其他测量因素包括年龄、母语、教育程度、标准化社会经济指数、吸烟情况、既往或当前抑郁症治疗史、认知障碍(简易精神状态检查表得分<24)和体重指数(BMI)。

结果

患有抑郁症的参与者(n = 340)比无抑郁症的对照组年龄更大(年龄:76.6±4.4岁对75.4±4.1岁)。CRP浓度>3mg/l的男性与CRP≤3mg/l的男性相比,患抑郁症的比值比(OR)增加[1.59,95%置信区间(CI)1.20 - 2.11]。一旦我们对身体共病测量指标和其他混杂因素进行分析调整,这种关联就变得不显著了(OR 1.22,95%CI 0.86 - 1.73)。

结论

导致老年男性抑郁症状发生和维持的生理机制仍有待确定,但CRP浓度在这一过程中不太可能起重要作用。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验