Kang Kwi Young, Jung Young-Eun, Jang Hwan, Kim Moon-Doo, Bahk Won-Myong
Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Division of Rheumatology, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea.
Clin Psychopharmacol Neurosci. 2021 Nov 30;19(4):721-730. doi: 10.9758/cpn.2021.19.4.721.
The relationship among physical functional decline, low-grade inflammation, and depression remains unclear. The aim of this study was to examine the association between hand grip strength (HGS) and high-sensitivity C-reactive protein (hs-CRP) in a large sample with depression.
This study used data obtained from a representative Korean sample of 9,402 people who participated in the seventh Korean National Health and Nutrition Examination Survey. Physical function was assessed using a digital grip strength dynamometer. Depression was identified using a cutoff of 5 on the Patient Health Questionnaire-9 (PHQ-9), and high hs-CPR level was defined as ≥ 3.0 mg/L.
In older adults (≥ 60 years) with depression, 43.8% of those with high hs-CRP levels had low HGS, compared to 21.8% of those with hs-CRP levels < 3.0 mg/L ( = 0.002). Multivariate analysis revealed that, after adjustments for potentially confounding factors, high hs-CRP was independently associated with lower HGS (B = -2.25; 95% confidence interval = -4.49 to -0.02) in older adults with depression, but not in younger or middle-aged adults with depression.
These findings suggest a significant correlation between physical functional decline and low-grade inflammation in older adults with depression.
身体功能衰退、低度炎症与抑郁症之间的关系仍不明确。本研究旨在探讨在一个大型抑郁症样本中握力（HGS）与高敏C反应蛋白（hs-CRP）之间的关联。
本研究使用了从9402名参与第七次韩国国民健康与营养检查调查的具有代表性的韩国样本中获得的数据。使用数字握力测力计评估身体功能。使用患者健康问卷-9（PHQ-9）中5分的临界值来确定抑郁症，高hs-CPR水平定义为≥3.0mg/L。
在患有抑郁症的老年人（≥60岁）中，hs-CRP水平高的人中有43.8%握力低，而hs-CRP水平<3.0mg/L的人中有21.8%握力低（P=0.002）。多变量分析显示，在对潜在混杂因素进行调整后，高hs-CRP与患有抑郁症的老年人较低的握力独立相关（B=-2.25；95%置信区间=-4.49至-0.02），但在患有抑郁症的年轻人或中年人中并非如此。
这些发现表明，患有抑郁症的老年人身体功能衰退与低度炎症之间存在显著相关性。
