Serra-Guillén C, Requena C, Alfaro A, Hueso L, Sanmartín O, Llombart B, Nagore E, Botella-Estrada R, Martorell-Calatayud A, Guillén C
Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, España.
Actas Dermosifiliogr. 2007 May;98(4):265-7.
Lymphomatoid papulosis is a cutaneous lymphoma with an indolent clinical behaviour characterized by chronic development of recurrent, self-limited lesions appearing as necrotic papules and with a pathology compatible with T cell lymphoma. Mucosal involvement by lymphomatoid papulosis is very rare but has been reported in the literature. It usually appears as ulcers in patients previously diagnosed of lymphomatoid papulosis. From a histological perspective it is characterized by an infiltrate of CD 30 positive atypical lymphocytes together with a mixed inflammatory infiltrate of eosinophils, neutrophils, histiocytes and plasma cells. We report the case of a man previously diagnosed of lymphomatoid papulosis that developed two ulcerated lesions in the tongue whose biopsy confirmed the diagnosis of oral involvement by lymphomatoid papulosis.
淋巴瘤样丘疹病是一种具有惰性临床行为的皮肤淋巴瘤，其特征为反复出现的自限性病变呈慢性发展，表现为坏死性丘疹，病理表现与T细胞淋巴瘤相符。淋巴瘤样丘疹病累及黏膜非常罕见，但文献中有相关报道。在先前诊断为淋巴瘤样丘疹病的患者中，黏膜受累通常表现为溃疡。从组织学角度来看，其特征是CD30阳性非典型淋巴细胞浸润，同时伴有嗜酸性粒细胞、中性粒细胞、组织细胞和浆细胞的混合性炎症浸润。我们报告一例先前诊断为淋巴瘤样丘疹病的男性患者，其舌部出现两处溃疡性病变，活检证实为淋巴瘤样丘疹病累及口腔。
