Aguggia M, D'Andrea G, Bussone G
Neurological Department, Via E. Raggio 12, I-15057 Novi Ligure (AL), Italy.
Neurol Sci. 2007 May;28 Suppl 2:S97-S100. doi: 10.1007/s10072-007-0759-3.
Migraine is an episodic brain disorder that results in significant morbidity. Antiepileptic drugs (neuromodulators) are increasingly recommended for migraine prevention because of placebo-controlled double-blind trials that prove them effective. Cortical spreading depression (CSD) is thought to be the pathophysiological correlate of the neurological symptoms in migraine with aura and neuromodulators may act on mechanisms involved in the initiation of CSD itself. Inhibition of trigeminocervical complex directly, or neurons that modulate sensory input, are also plausible mechanisms for the actions of neuromodulators in preventive therapy in migraine. Although it is unlikely that a single phenomenon serves as the only link between migraine and epilepsy, the neuronal hyperexcitability that may contribute to each condition may explain the effect of these drugs for both conditions.
偏头痛是一种发作性脑疾病，会导致严重的发病率。由于安慰剂对照双盲试验证明抗癫痫药物（神经调节剂）有效，因此越来越多地被推荐用于预防偏头痛。皮层扩散性抑制（CSD）被认为是偏头痛伴先兆的神经症状的病理生理相关因素，神经调节剂可能作用于参与CSD起始的机制。直接抑制三叉神经颈复合体或调节感觉输入的神经元，也是神经调节剂在偏头痛预防性治疗中发挥作用的合理机制。虽然不太可能有单一现象是偏头痛和癫痫之间的唯一联系，但可能导致这两种疾病的神经元过度兴奋性或许可以解释这些药物对这两种疾病的疗效。
