Levinthal David J, Kuo Braden
Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Center for Neurointestinal Health, Massachusetts General Hospital, Boston, Massachusetts, USA.
Neurogastroenterol Motil. 2025 Mar;37(3):e14991. doi: 10.1111/nmo.14991. Epub 2024 Dec 31.
Cyclic vomiting syndrome (CVS) is defined by its episodic patterning. Furthermore, CVS is associated with other episodic disorders such as migraine and epilepsy. Indeed, many of the medications that are known to be useful for prophylaxis and abortive therapy in CVS are also effective in preventing and aborting migraines and seizures. These observations strongly suggest that CVS has a neural basis, but the precise pathophysiological mechanisms that operate in CVS remain unclear.
This brief review describes recent neurophysiological insights and opportunities to further advance the understanding of pathophysiological neural mechanisms that are present in patients with CVS. These insights are poised to translate into the next generation of neurotherapeutic strategies for CVS using central neuromodulation. Additionally, the development of neurophysiological tests of neural excitability could be positioned to shape management decisions in future CVS care.
周期性呕吐综合征（CVS）由其发作模式定义。此外，CVS与其他发作性疾病如偏头痛和癫痫相关。实际上，许多已知对CVS预防和中止治疗有用的药物在预防和中止偏头痛及癫痫发作方面也有效。这些观察结果强烈表明CVS有神经基础，但CVS中起作用的精确病理生理机制仍不清楚。
本简要综述描述了最近的神经生理学见解以及进一步推进对CVS患者存在的病理生理神经机制理解的机会。这些见解有望转化为使用中枢神经调节的CVS下一代神经治疗策略。此外，神经兴奋性神经生理学测试的发展可能会影响未来CVS护理中的管理决策。
Zotero 插件