Castellani Rudy J, Moreira Paula I, Liu Gang, Dobson Jon, Perry George, Smith Mark A, Zhu Xiongwei
Department of Pathology, University of Maryland, Baltimore, MD, USA.
Neurochem Res. 2007 Oct;32(10):1640-5. doi: 10.1007/s11064-007-9360-7. Epub 2007 May 17.
Although iron is essential in maintaining the function of the central nervous system, it is a potent source of reactive oxygen species. Excessive iron accumulation occurs in many neurodegenerative diseases including Alzheimer disease (AD), Parkinson's disease, and Creutzfeldt-Jakob disease, raising the possibility that oxidative stress is intimately involved in the neurodegenerative process. AD in particular is associated with accumulation of numerous markers of oxidative stress; moreover, oxidative stress has been shown to precede hallmark neuropathological lesions early in the disease process, and such lesions, once present, further accumulate iron, among other markers of oxidative stress. In this review, we discuss the role of iron in the progression of AD.
尽管铁对于维持中枢神经系统的功能至关重要，但它也是活性氧的重要来源。在包括阿尔茨海默病（AD）、帕金森病和克雅氏病在内的许多神经退行性疾病中都存在过量的铁积累，这增加了氧化应激与神经退行性过程密切相关的可能性。特别是AD与多种氧化应激标志物的积累有关；此外，在疾病过程早期，氧化应激已被证明先于标志性神经病理损伤出现，并且一旦出现这些损伤，除了其他氧化应激标志物外，还会进一步积累铁。在这篇综述中，我们讨论了铁在AD进展中的作用。
