Ocheni S, Ibegbulam O G, Okafor O C, Raveenthiran V, Nzegwu M A
Department of Haematology and Immunology, University of Nigeria, Enugu Campus, Enugu, Nigeria.
Eur J Cancer Care (Engl). 2007 May;16(3):286-8. doi: 10.1111/j.1365-2354.2006.00746.x.
Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is a benign self-limiting disorder of unknown aetiology, which is frequently mistaken for lymphoma. There is no consensus as to the proper management of this disorder. In the past, potentially harmful treatments, such as antineoplastic drugs, have been advocated. We describe a 25-year-old woman with RDD who has had a remarkably favourable response to oral prednisolone therapy. Our observation strengthens the conclusions of previous case reports as to the effectiveness of corticosteroids in this condition. This article is aimed at creating awareness among clinical oncologists about this pseudolymphomatous disorder and emphasizing the therapeutic role of corticosteroids.
罗萨伊-多夫曼病（RDD），又称伴有巨大淋巴结病的窦性组织细胞增生症，是一种病因不明的良性自限性疾病，常被误诊为淋巴瘤。对于这种疾病的恰当治疗尚无共识。过去，有人主张使用如抗肿瘤药物等潜在有害的治疗方法。我们描述了一名25岁患有RDD的女性，她对口服泼尼松龙治疗有显著良好的反应。我们的观察结果强化了先前病例报告中关于皮质类固醇在这种疾病中的有效性的结论。本文旨在提高临床肿瘤学家对这种假性淋巴瘤疾病的认识，并强调皮质类固醇的治疗作用。
