Maher Mary Grey, Mourtzinos Arthur, Zabihi Nasim, Laiwalla U Zehra, Raz Shlomo, Rodríguez Larissa V
The Urology Center, New Haven, Connecticut, USA.
J Urol. 2007 Jun;177(6):2237-40; discussion 2241. doi: 10.1016/j.juro.2007.01.147.
Sacral neuromodulation with InterStim is approved for idiopathic urinary retention with a success rate of approximately 69%. To our knowledge currently no alternatives exist for patients in whom S3 neuromodulation fails. We report a new technique and our experience with bilateral caudal epidural neuromodulation in patients in urinary retention in whom unilateral or bilateral S3 InterStim failed.
Eight patients with multifactorial urinary retention in whom S3 InterStim previously failed underwent retrograde placement of bilateral tined leads into the caudal epidural space for sacral nerve stimulation. Patients with a 50% or greater clinical response underwent stage 2 Synergy-Versitrel implantable pulse generator placement. Patients were evaluated with voiding diaries, the Urinary Distress Inventory Questionnaire short form, quality of life assessment, need for catheterization and post-void residual urine preoperatively, and 6 months after implantation.
Five of the 8 patients experienced return of micturition and underwent placement of a permanent implantable pulse generator. At 6-month followup 4 of the 5 patients voided to completion. One patient improved more than 50% and now catheterizes once daily with a post-void residual urine of 200 cc. There was a significant decrease in obstructive symptoms on the Urinary Distress Inventory Questionnaire short form and improved overall quality of life.
To our knowledge this is the first report of the use of bilateral caudal epidural neuromodulation for refractory urinary retention. This therapy can be successful in patients in whom prior InterStim therapy failed.
InterStim骶神经调节疗法已被批准用于特发性尿潴留,成功率约为69%。据我们所知,目前对于S3神经调节失败的患者尚无其他替代方案。我们报告一种新技术以及我们在单侧或双侧S3 InterStim失败的尿潴留患者中进行双侧尾段硬膜外神经调节的经验。
8例多因素导致尿潴留且先前S3 InterStim治疗失败的患者接受了双侧带倒刺电极逆行置入尾段硬膜外间隙以进行骶神经刺激。临床反应达到50%或更高的患者接受了第二阶段的Synergy-Versitrel植入式脉冲发生器置入。术前以及植入后6个月,通过排尿日记、简化版排尿困难量表问卷、生活质量评估、导尿需求和残余尿量对患者进行评估。
8例患者中有5例恢复排尿并接受了永久性植入式脉冲发生器置入。在6个月的随访中,5例患者中有4例排尿完全。1例患者改善超过50%,现在每天导尿一次,残余尿量为200 cc。简化版排尿困难量表问卷中的梗阻症状显著减轻,整体生活质量得到改善。
据我们所知,这是首次关于使用双侧尾段硬膜外神经调节治疗难治性尿潴留的报告。这种疗法对于先前InterStim治疗失败的患者可能有效。