Tsuchiya Kenji J, Hashimoto Kenji, Iwata Yasuhide, Tsujii Masatsugu, Sekine Yoshimoto, Sugihara Genichi, Matsuzaki Hideo, Suda Shiro, Kawai Masayoshi, Nakamura Kazuhiko, Minabe Yoshio, Yagi Atsuko, Iyo Masaomi, Takei Nori, Mori Norio
Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
Biol Psychiatry. 2007 Nov 1;62(9):1056-8. doi: 10.1016/j.biopsych.2006.12.018. Epub 2007 May 23.
Accumulating evidence suggests that the immune system plays a role in the pathophysiology of autism, and that the adhesion molecules play an important role in the process of inflammation. This study was undertaken to determine whether serum levels of the adhesion molecules in subjects with high-functioning autism are altered as compared with those of normal controls.
Seventeen male subjects with high-functioning autism and 22 male age-matched unrelated healthy control subjects were enrolled. Serum levels of the soluble forms of platelet-endothelial adhesion molecule (PECAM-1), intracellular adhesion molecule (ICAM-1), and vascular cell adhesion molecule (VCAM-1) were measured.
Levels of PECAM-1, but not ICAM-1, in the subjects with autism were significantly lower than those of control subjects. VCAM-1 showed a weak trend for a lowered level. There was a negative correlation between serum levels of PECAM-1 and head circumference at birth in the autistic subjects.
These results suggest that PECAM-1 plays a role in the pathophysiology of high-functioning autism.
越来越多的证据表明，免疫系统在自闭症的病理生理学中发挥作用，并且黏附分子在炎症过程中起重要作用。本研究旨在确定高功能自闭症患者血清中黏附分子水平与正常对照组相比是否发生改变。
招募了17名高功能自闭症男性受试者和22名年龄匹配的无关健康男性对照受试者。测量了血小板内皮黏附分子（PECAM-1）、细胞间黏附分子（ICAM-1）和血管细胞黏附分子（VCAM-1）可溶性形式的血清水平。
自闭症受试者中PECAM-1的水平显著低于对照受试者，而ICAM-1的水平则无显著差异。VCAM-1水平呈降低的微弱趋势。自闭症受试者中PECAM-1血清水平与出生时头围之间存在负相关。
这些结果表明PECAM-1在高功能自闭症的病理生理学中发挥作用。
