Wang Yiran, Yu Shunyu, Li Mengqian
Queen Mary School, Jiangxi Medical College, Nanchang University, Nanchang, China.
Department of Psychosomatic Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Front Cell Neurosci. 2023 Aug 24;17:1226580. doi: 10.3389/fncel.2023.1226580. eCollection 2023.
Normal brain development, function, and aging critically depend on unique characteristics of the cerebrovascular system. Growing evidence indicated that cerebrovascular defects can have irreversible effects on the brain, and these defects have been implicated in various neurological disorders, including autism spectrum disorder (ASD). ASD is a neurodevelopmental disorder with heterogeneous clinical manifestations and anatomical changes. While extensive research has focused on the neural abnormalities underlying ASD, the role of brain vasculature in this disorder remains poorly understood. Indeed, the significance of cerebrovascular contributions to ASD has been consistently underestimated. In this work, we discuss the neurovascular crosstalk during embryonic development and highlight recent findings on cerebrovascular alterations in individuals with ASD. We also discuss the potential of vascular-based therapy for ASD. Collectively, these investigations demonstrate that ASD can be considered a neurovascular disease.
正常的大脑发育、功能及衰老严重依赖于脑血管系统的独特特性。越来越多的证据表明，脑血管缺陷会对大脑产生不可逆的影响，并且这些缺陷与包括自闭症谱系障碍（ASD）在内的各种神经系统疾病有关。ASD是一种具有异质性临床表现和解剖学变化的神经发育障碍。虽然广泛的研究集中在ASD潜在的神经异常方面，但大脑血管系统在这种疾病中的作用仍知之甚少。事实上，脑血管对ASD的作用一直被低估。在这项工作中，我们讨论了胚胎发育过程中的神经血管相互作用，并强调了近期关于ASD个体脑血管改变的研究结果。我们还讨论了基于血管的ASD治疗潜力。总体而言，这些研究表明ASD可被视为一种神经血管疾病。
