Smythe Jon, Armitage Sue, McDonald Dorothy, Pamphilon Derwood, Guttridge Martin, Brown Juliette, Green Ann, Brown Colin, Warwick Ruth M, Lankester Alan, Fehily Deirdre, Contreras Marcela, Navarrete Cristina, Watt Suzanne M
Stem Cells and Immunotherapies Department, National Blood Service, NHS Blood and Transplant, Headington, Oxford, UK.
Stem Cells. 2007 Aug;25(8):2087-93. doi: 10.1634/stemcells.2007-0063. Epub 2007 May 17.
Umbilical cord blood (UCB) is an important source of hematopoietic stem cells for transplantation. Although UCB is often collected from unrelated donors, directed umbilical cord blood (DCB) from sibling donors also provides an important source of UCB for transplantation. This report summarizes the experience in collection, testing, storage, and transplantation of DCB units by the National Blood Service for England and North Wales over 10 years. Eligibility for collection was based on an existing sibling suffering from a disease that may be treated by stem cell transplantation or a family history that could result in the birth of a sibling with a disease that could be treated by stem cell transplantation. Collections were made on the provision that the sibling's clinician was willing to financially support the collection and to take responsibility for medical review of the mother and potential recipient. Given the high investment in UCB banking and the introduction of new regulations and mandatory licensing under the European Union Tissues and Cells Directive and those proposed in the U.S., this report details the procedures that we have used for DCB donations, the outcome data where donations have been used for transplantation, and it provides some timely recommendations for best practices. Disclosure of potential conflicts of interest is found at the end of this article.
脐带血（UCB）是用于移植的造血干细胞的重要来源。尽管脐带血通常采集自非亲属捐赠者，但来自同胞捐赠者的定向脐带血（DCB）也是用于移植的脐带血的重要来源。本报告总结了英格兰和北威尔士国家血液服务机构在10年期间采集、检测、储存和移植DCB单位的经验。采集的资格基于现有同胞患有可能通过干细胞移植治疗的疾病，或基于家族病史，该病史可能导致出生患有可通过干细胞移植治疗疾病的同胞。采集工作的前提是同胞的临床医生愿意在经济上支持采集，并负责对母亲和潜在接受者进行医学评估。鉴于脐带血库的高投入以及欧盟组织和细胞指令以及美国提议的新法规和强制许可的出台，本报告详细介绍了我们用于DCB捐赠的程序、捐赠用于移植的结果数据，并提供了一些关于最佳实践的及时建议。潜在利益冲突的披露见本文末尾。
