Department of Immunoematologia e Medicina Trasfusionale, Azienda Policlinico Umberto I, Via Chieti N°7, 00161, Rome, Italy,
Stem Cell Rev Rep. 2015 Apr;11(2):275-9. doi: 10.1007/s12015-014-9579-z.
Family-directed umbilical cord blood (UCB) collection and banking is indicated in women delivering healthy babies who already have a member of their own family with a disease potentially treatable with an allogeneic hematopoietic stem cell (HSCs) transplantation (HSCT). The rapid availability of UCB is an important issue in HSCs procurement particularly for recipients with acute leukemia who urgently need HSCT. The aims of this study were to assess the usage rate of family UCB collections directed to patients with acute leukemia and to investigate the factors influencing the usage rate. A total of 113 families were enrolled, 118 UCB units were successfully collected and one collection failed due to emergency occurred during delivery. Among these, 7 collections were required for children who were in urgent need of a transplant: three HLA-matched units were successfully transplanted, respectively after 2, 5 and 6 months from collection; three collections resulted HLA-mismatched, while HLA-typing is pending for one unit. The remaining collections were mostly required for potential future use, among these units only one was transplanted in a HLA compatible sibling after 3 years and 4 months from collection. After a median time of storage of 8.5 years (range 0.1-20 years) a total of 4/118 (3.4 %) collection has been transplanted. During this time interval, considering only patients who have had the need of a transplant, the main factor influencing low utilization rate of UCB collections was due to HLA disparity, indeed among typed UCB unit mostly (77 %) resulted HLA mismatched with the intended recipient.
家庭导向的脐带血（UCB）采集和储存适用于已经有家庭成员患有可通过同种异体造血干细胞（HSCs）移植（HSCT）治疗的疾病的分娩健康婴儿的女性。UCB 的快速可用性是 HSCs 采集的一个重要问题，特别是对于急需 HSCT 的急性白血病患者。本研究的目的是评估家庭 UCB 采集在急性白血病患者中的使用情况，并调查影响使用的因素。共纳入 113 个家庭，成功采集了 118 个 UCB 单位，由于分娩期间发生紧急情况，有一个采集失败。其中，7 个采集是为急需移植的儿童提供的：三个 HLA 匹配的单位分别在采集后 2、5 和 6 个月成功移植；三个采集结果 HLA 不匹配，而一个单位的 HLA 分型仍在等待中。其余的采集大多是为潜在的未来使用而保留的，在这些单位中，只有一个在采集后 3 年零 4 个月在 HLA 相容的兄弟姐妹中进行了移植。在中位储存时间为 8.5 年（范围为 0.1-20 年）后，共有 4/118（3.4%）的采集进行了移植。在此时间间隔内，仅考虑需要移植的患者，UCB 采集利用率低的主要因素是由于 HLA 不匹配，实际上，在已分型的 UCB 单位中，大多数（77%）与预期受者 HLA 不匹配。
