Sandlund Johanna, Hedberg Ylva, Bergh Anders, Grankvist Kjell, Ljungberg Börje, Rasmuson Torgny
Division of Oncology, Department of Radiation Sciences, Umeå University, Umeå, Sweden.
Tumour Biol. 2007;28(3):158-64. doi: 10.1159/000102980. Epub 2007 May 18.
Intratumoural microvessel density (MVD) has prognostic significance in selected neoplasms. To evaluate the prognostic information of MVD in renal cell carcinoma (RCC) we assessed the immunohistochemical expression of CD31 in 208 tumours using the tissue microarray technique. The expression was related to tumour cell type, TNM stage, nuclear grade and survival. CD31 expression was significantly (p < 0.001) higher in 167 conventional RCCs (clear cell) compared to 28 papillary RCCs. In conventional RCC, CD31 expression was inversely correlated to TNM stage (p = 0.024) and nuclear grade (p = 0.010). To evaluate the impact of CD31 expression on tumour-specific survival, the conventional RCC tumours were subdivided into quartiles according to the CD31 expression. In univariate analysis, patients with tumours in the quartile with the highest expression had a more favourable prognosis (p = 0.01) compared to those with lower CD31 expression. A multivariate analysis of prognostic factors in conventional RCC showed that TNM stage and nuclear grade were independent predictors of prognosis, but CD31 expression did not add further prognostic information.
肿瘤内微血管密度（MVD）在某些肿瘤中具有预后意义。为了评估MVD在肾细胞癌（RCC）中的预后信息，我们使用组织芯片技术评估了208例肿瘤中CD31的免疫组化表达。该表达与肿瘤细胞类型、TNM分期、核分级及生存率相关。与28例乳头状RCC相比，167例传统RCC（透明细胞型）中的CD31表达显著更高（p < 0.001）。在传统RCC中，CD31表达与TNM分期（p = 0.024）及核分级（p = 0.010）呈负相关。为了评估CD31表达对肿瘤特异性生存的影响，根据CD31表达将传统RCC肿瘤分为四分位数。单因素分析显示，与CD31表达较低的患者相比，CD31表达最高四分位数的肿瘤患者预后更优（p = 0.01）。对传统RCC预后因素的多因素分析表明，TNM分期和核分级是预后的独立预测因素，但CD31表达并未增加更多的预后信息。
