Singh Gajinder Pal, Dash Debasis
Institute of Genomics and Integrative Biology, Delhi University Campus, Delhi, India.
Proteins. 2007 Aug 15;68(3):602-5. doi: 10.1002/prot.21497.
Intrinsic disorder has been shown to be important in mediating protein-protein and protein-DNA interactions. Proteins involved in regulatory functions are particularly enriched in intrinsic disorder. In this study we explored the role of intrinsic disorder in transcriptional regulatory network of yeast. Using disorder prediction programs we show that transcription factors (TFs) regulating large number of targets (transcriptional hubs) have significantly increased intrinsic disorder, though targets regulated by multiple TFs did not show increased intrinsic disorder. Intrinsic disorder may allow these transcriptional hubs to bind to diverse promoter regions of their targets in different contexts, and may also allow complex regulatory control of transcriptional hubs that are involved in coordinating different cellular processes.
内在无序已被证明在介导蛋白质-蛋白质和蛋白质-DNA相互作用中很重要。参与调节功能的蛋白质尤其富含内在无序。在本研究中，我们探讨了内在无序在酵母转录调控网络中的作用。使用无序预测程序，我们发现调控大量靶标的转录因子（TFs）（转录枢纽）的内在无序显著增加，尽管受多个TFs调控的靶标并未显示出内在无序增加。内在无序可能使这些转录枢纽在不同情况下与它们靶标的不同启动子区域结合，并且还可能允许对参与协调不同细胞过程的转录枢纽进行复杂的调控。
