Cao Ping, Huang Xian-Feng, Ding Hui, Ge Hui-Ming, Li Huan-Qiu, Ruan Ban-Feng, Zhu Hai-Liang
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China.
Chem Biodivers. 2007 May;4(5):881-6. doi: 10.1002/cbdv.200790075.
A series of substituted urea derivatives, compounds 1-14, were synthesized and evaluated for their cytotoxic activities against the human-leukemia K562 cell line. Two structurally simple compounds, 7 and 12, both incorporating a morpholine ring, were found to be highly active, with IC50 values of ca. 0.25 microM.
