Synthesis of New -Lactams Bearing the Biologically Important Morpholine Ring and POM Analyses of Their Antimicrobial and Antimalarial Activities.

Some new lactams bearing biologically important morpholine ring have been synthesized by acylation of amino lactams in the presence of morpholine-4-carbonyl chloride. These novel -lactams were prepared under mild reaction conditions without any solvent in short reaction times. Their biological activities have been examined against microbial agents such as () (), () and fungi such as () and (). They have been also tested against K14 resistant strain and showed moderate to good IC values.