Li Yan-Fang, Li Jia, Shen Qiang, Hu Li-Hong
Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China.
Chem Biodivers. 2007 May;4(5):961-5. doi: 10.1002/cbdv.200790086.
From the whole plant of Ardisia japonica, four [1,4]benzoquinones were isolated by means of bioassay-directed fractionation of the EtOH extract. Apart from the two known compounds maesanin (1) and its congener 2, two new benzoquinones, i.e., 5-ethoxy-2-hydroxy-3-[(10Z)-pentadec-10-en-1-yl][1,4]benzoquinone (3) and 5-ethoxy-2-hydroxy-3-[(8Z)-tridec-8-en-1-yl][1,4]benzoquinone (4), were identified. All compounds showed significant in vitro bioactivities against the PTP1B enzyme, with IC50 values in the range of ca. 3-19 microM.
通过对紫金牛乙醇提取物进行生物活性导向分离，从紫金牛全草中分离出了四种[1,4]苯醌。除了两种已知化合物迈森宁（1）及其同系物2外，还鉴定出了两种新的苯醌，即5-乙氧基-2-羟基-3-[(10Z)-十五碳-10-烯-1-基][1,4]苯醌（3）和5-乙氧基-2-羟基-3-[(8Z)-十三碳-8-烯-1-基][1,4]苯醌（4）。所有化合物对蛋白酪氨酸磷酸酶1B（PTP1B）酶均显示出显著的体外生物活性，IC50值约为3-19微摩尔。
