Medeiros L Jeffrey, Elenitoba-Johnson Kojo S J
Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030-4095, USA.
Am J Clin Pathol. 2007 May;127(5):707-22. doi: 10.1309/r2q9ccuvtlrycf3h.
Session 8 of the 2005 Society of Hematopathology/European Association for Haematopathology Workshop was devoted to anaplastic large cell lymphoma (ALCL). Most cases submitted were anaplastic lymphoma kinase (ALK)+ ALCL highlighting unusual clinical settings, histologic variants, and variant translocation partners. Cases submitted as ALK- ALCL emphasized the immunohistochemical overlap with classical Hodgkin lymphoma (eg, CD15+/CD30+). It was also clear that consensus histologic and immunohistochemical criteria for the diagnosis of ALK-ALCL are lacking. Many expressed the opinion that ALK-ALCL is not a distinct entity at the immunophenotypic or genetic level and is better designated as peripheral T-cell lymphoma (PTCL), unspecified. Others suggested that the histologic features of ALK-ALCL are distinctive nevertheless and that this diagnosis has meaning that is lost by designating these neoplasms as PTCL, unspecified. This session also included CD30+ anaplastic lymphomas involving skin in which the differential diagnosis included cutaneous ALCL and systemic ALK-ALCL.
2005年血液病理学学会/欧洲血液病理学协会研讨会的第8场会议专门讨论了间变性大细胞淋巴瘤（ALCL）。提交的大多数病例为间变性淋巴瘤激酶（ALK）阳性的ALCL，突出了其不寻常的临床情况、组织学变异型及变异的易位伙伴。作为ALK阴性的ALCL提交的病例强调了其与经典霍奇金淋巴瘤在免疫组化方面的重叠（如CD15+/CD30+）。同样明显的是，目前缺乏用于诊断ALK阴性ALCL的共识性组织学和免疫组化标准。许多人认为，ALK阴性的ALCL在免疫表型或基因水平上并非一个独特的实体，最好将其归为未特指的外周T细胞淋巴瘤（PTCL）。其他人则认为，ALK阴性ALCL的组织学特征仍然具有独特性，将这些肿瘤诊断为未特指的PTCL会失去其应有的意义。本次会议还包括累及皮肤的CD30阳性间变性淋巴瘤，其鉴别诊断包括皮肤ALCL和系统性ALK阴性ALCL。
