[血竭缓释微球的体外制备及评价]
[Preparation and evaluation of sustained-release microsphere of Sanguis Draconis in vitro].
作者信息
Ding Li-Yu, Xia Peng-Fei, Yang Cai-Qin, Lin Yu-Long, Wang Jing
机构信息
Department of Inorganic and Physical Chemistry, College of Pharmacy Hebei Medical University, Shijiazhuang 050017, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2007 Mar;32(5):388-90.
OBJECTIVE
To prepare sustained-release microsphere containing extract of Sanguis Draconis and to measure its dissolution in vitro.
METHOD
Sustained-release microsphere was prepared with polylactic acid (PLA) as carriers using the oil-in-water (O/W) emulsion solvent evaporation method. The powder particle's characteristics of sustainded-release microsphere were evaluated comprehensively, and its dissolution characteristics in vitro were studied.
RESULT
The microsphere was round and its surface was smooth, drug-loading rate was 21.97% and the entrapment rate was 55.76%, the accumulative release percentage was 76. 71% in 16 hours.
CONCLUSION
The sustained release effect of Sanguis Draconis microspheres was formed with potentially wide applications.
目的
制备含血竭提取物的缓释微球并测定其体外溶出度。
方法
以聚乳酸（PLA）为载体，采用水包油（O/W）乳液溶剂挥发法制备缓释微球。综合评价缓释微球的粉体颗粒特性，并研究其体外溶出特性。
结果
微球呈圆形，表面光滑，载药率为21.97%，包封率为55.76%，16小时累积释放率为76.71%。
结论
血竭微球具有缓释效果，具有潜在的广泛应用前景。
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