Wang Chunfang, Liu Zheng, Huang Xiaowen, Xu Kai
Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2007 Feb;21(4):167-8.
To investigate the curative effect of corticosteroid on acute otitis media (AOM) with middle ear effusion.
Forty-three children (43 ears) with AOM and abnormal tympanogram were enrolled in a prospective, randomized trial. Twenty-three cases (23 ears) were treated with Dexamethasone and Cefuroxime Sodium, while the other 20 cases (20 ears) were only treated with Cefuroxime Sodium.
The period of normalization of tympanometric findings in Dexamethasone treatment group was (54.6+/-6.2) days, which was much longer than that in the group without Dexamethasone treatment (38.5+/-6.1). Three months after treatment, the curative rate of Dexamethasone treatment group was higher than that of the group without Dexamethasone treatment.
Corticosteroid can obviously improve middle ear effusion and shorten the duration of middle ear effusion of AOM in the first 2 weeks. To some extent, corticosteroid can also improve middle ear effusion in long term. It indicates that corticosteroid be used as an effective adjunctive drug in treating AOM with middle ear effusion.
探讨糖皮质激素对伴中耳积液的急性中耳炎（AOM）的疗效。
43例鼓膜图异常的AOM患儿（43耳）纳入一项前瞻性随机试验。23例（23耳）采用地塞米松和头孢呋辛钠治疗，另外20例（20耳）仅采用头孢呋辛钠治疗。
地塞米松治疗组鼓室图结果恢复正常的时间为（54.6±6.2）天，明显长于未用地塞米松治疗组（38.5±6.1）天。治疗3个月后，地塞米松治疗组的治愈率高于未用地塞米松治疗组。
糖皮质激素可明显改善中耳积液，并缩短AOM最初2周内中耳积液的持续时间。在一定程度上，糖皮质激素也可长期改善中耳积液。这表明糖皮质激素可作为治疗伴中耳积液的AOM的有效辅助药物。
