植入全人工心脏动物体内的微生物感染性血栓

Microbially infected thrombus in animals with total artificial hearts.

作者信息

Chiang B Y, Burns G L, Pantalos G M, Dew P A, Kinoshita M, White R K, Mohammad S F, Olsen D B

机构信息

Institute for Biomedical Engineering, University of Utah, Salt Lake City 84103.

出版信息

ASAIO Trans. 1991 Jul-Sep;37(3):M256-7.

PMID:1751136

Abstract

In a retrospective study of 330 animals with total artificial hearts (TAH), 103 (31%) had microbially infected thrombi (MIT). The incidence of MIT approximated 75% in the animals surviving more than 100 days. The most common pathogen isolated from animals with MIT was Pseudomonas. Most thrombi appeared to have originated from valve junctions and connectors. Methods to prevent MIT should be aimed at eliminating thrombus formation by improved design and materials and controlling the route of bacterial colonization. These findings suggest that bacterial interaction with the thrombus, device-related bacterial colonization, host immunomodulation, and gut barrier function after TAH implantation need further study.

摘要

在一项对330只植入全人工心脏（TAH）动物的回顾性研究中，103只（31%）出现了微生物感染性血栓（MIT）。在存活超过100天的动物中，MIT的发生率约为75%。从患有MIT的动物中分离出的最常见病原体是假单胞菌。大多数血栓似乎起源于瓣膜连接处和连接部位。预防MIT的方法应旨在通过改进设计和材料消除血栓形成，并控制细菌定植途径。这些发现表明，TAH植入后细菌与血栓的相互作用、与装置相关的细菌定植、宿主免疫调节和肠道屏障功能需要进一步研究。