von Segesser L K, Weiss B M, Bisang B, Leskosek B, Turina M I
Clinic for Cardiovascular Surgery, University Hospital, Zürich, Switzerland.
ASAIO Trans. 1991 Jul-Sep;37(3):M278-9.
Heparin surface coated ventricular assist devices (VADs) were evaluated without systemic heparinization and compared with uncoated control VADs with systemic heparinization (bovine experiments, n = 8; bodyweight, 75 +/- 6 kg). No heparin was given in the study group, whereas heparin (300 IU/kg) was given before cannulation in the control group. Mean activated clotting time (ACT) was 127 +/- 12 sec before and 122 +/- 17 sec after 6 hours of left ventricular assist for coated (NS) versus 184 +/- 114 sec before and 650 +/- 240 sec after for uncoated (p less than 0.05) VADs. No difference was observed in platelet depletion, plasma hemoglobin, lactic dehydrogenase (LDH) production, mixed venous oxygen saturation, and VAD clot score. No VAD occlusions occurred. Ventricular assist can be achieved without systemic heparinization if VADs are improved.
对肝素表面涂层的心室辅助装置（VAD）在未进行全身肝素化的情况下进行了评估，并与进行全身肝素化的未涂层对照VAD进行了比较（牛实验，n = 8；体重，75±6 kg）。研究组未给予肝素，而对照组在插管前给予肝素（300 IU/kg）。对于涂层VAD，左心室辅助6小时前平均活化凝血时间（ACT）为127±12秒，6小时后为122±17秒（无显著性差异）；而对于未涂层VAD，左心室辅助6小时前平均活化凝血时间为184±114秒，6小时后为650±240秒（p<0.05）。在血小板消耗、血浆血红蛋白、乳酸脱氢酶（LDH）生成、混合静脉血氧饱和度和VAD血栓评分方面未观察到差异。未发生VAD堵塞。如果对VAD进行改进，不进行全身肝素化也可实现心室辅助。
