使脂质和多糖磷酸化的酶。

Enzymes phosphorylating lipids and polysaccharides.

作者信息

Karataeva N A, Nevinsky G A

机构信息

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.

出版信息

Biochemistry (Mosc). 2007 Apr;72(4):367-79. doi: 10.1134/s0006297907040037.

DOI:10.1134/s0006297907040037

PMID:17511601

Abstract

Phosphorylation plays an important role in regulation of living functions of organisms; phosphorylation may significantly alter chemical properties of proteins, lipids, and carbohydrates. Canonical kinases catalyze transfer of terminal phosphate group from ATP (or other NTPs) to specific nucleophilic groups of proteins, lipids, and polysaccharides. Recently, unique kinases, catalytically active antibodies (abzymes) phosphorylating proteins, lipids, and polysaccharides have also been discovered. This review highlights biological functions and enzymatic characteristics of canonical kinases and abzymes phosphorylating lipids and polysaccharides.

摘要

磷酸化在生物体生命功能的调节中起着重要作用；磷酸化可显著改变蛋白质、脂质和碳水化合物的化学性质。经典激酶催化将ATP（或其他NTP）的末端磷酸基团转移到蛋白质、脂质和多糖的特定亲核基团上。最近，还发现了独特的激酶，即能使蛋白质、脂质和多糖磷酸化的具有催化活性的抗体（抗体酶）。本文综述了使脂质和多糖磷酸化的经典激酶和抗体酶的生物学功能及酶学特性。