Arafa Mohamed, Eid Hazem, Shamloul Rany
Department of Andrology, Cairo University, Cairo, Egypt.
Int J Urol. 2007 May;14(5):476-7. doi: 10.1111/j.1442-2042.2006.01732.x.
Recently, it was reported that phentolamine redosing during penile duplex can abolish a false diagnosis of venous leakage in patients with impotence. The aim of this study is to identify any useful role of phentolamine redosing in diagnosis of venogenic impotence. Sixty-seven consecutive patients complaining of weak erection for at least 6 months were included in this study. Penile color Doppler ultrasound (CDU) was performed using a 7.5 MHz linear array transducer with a color flow mapping capability. Following intracavernous injection of 20 microg prostaglandin E1 (PGE1), all patients with persistent end diastolic velocity (EDV) >5 cm/sec with an erectile response of E3 or lower, 20 min after intracavernosal injection of PGE1, were asked to revisit our clinic for a second CDU, 2 weeks later. During initial CDU examination, all 67 patients experienced poor response to 20 microg PGE1 with their average peak systolic velocity (PSV) and EDV being 42.8 and 6.6 cm/sec, respectively. The second CDU examination had similar results to the first one. Addition of 2 mg phentolamine did not significantly change the PSV and EDV of cavernosal arteries in any of the 67 patients. In conclusion, addition of intracavernous phentolamine during PGE1 CDU examination carries no advantage over the use of PGE1 alone regarding cavernosal artery response in patients with suspected venogenic EDV.
最近有报道称，阴茎双功能超声检查期间再次注射酚妥拉明可消除对阳痿患者静脉漏的误诊。本研究的目的是确定再次注射酚妥拉明在诊断静脉性阳痿方面是否具有任何有用的作用。本研究纳入了67例连续抱怨阴茎勃起功能弱至少6个月的患者。使用具有彩色血流图功能的7.5MHz线性阵列换能器进行阴茎彩色多普勒超声（CDU）检查。海绵体内注射20μg前列腺素E1（PGE1）后，所有在海绵体内注射PGE1后20分钟时，持续舒张末期血流速度（EDV）>5cm/秒且勃起反应为E3或更低的患者，被要求在2周后返回我们的诊所进行第二次CDU检查。在初次CDU检查期间，所有67例患者对20μg PGE1的反应均较差，其平均收缩期峰值血流速度（PSV）和EDV分别为42.8cm/秒和6.6cm/秒。第二次CDU检查结果与第一次相似。添加2mg酚妥拉明并未使67例患者中的任何一例海绵体动脉的PSV和EDV发生显著变化。总之，在PGE1 CDU检查期间添加海绵体内酚妥拉明，在疑似静脉性EDV患者的海绵体动脉反应方面，并不比单独使用PGE1更具优势。
