Onnebo Sara Maria Nancy, Saiardi Adolfo
Medical Research Council (MRC) Cell Biology Unit and Laboratory for Molecular Cell Biology, Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.
Cell. 2007 May 18;129(4):647-9. doi: 10.1016/j.cell.2007.05.002.
Inositol pyrophosphates are unique signaling molecules implicated in the regulation of diverse cellular processes. Two new studies by Mulugu et al. (2007) and Lee et al. (2007) extend the biological and metabolic diversity of this class of molecules. They identify yeast Vip1 as a new inositol pyrophosphate synthase and show that the products of Vip1 activity regulate a cyclin/cyclin-dependent kinase complex.
肌醇焦磷酸是一类独特的信号分子，参与多种细胞过程的调控。Mulugu等人（2007年）和Lee等人（2007年）的两项新研究扩展了这类分子的生物学和代谢多样性。他们鉴定出酵母Vip1为一种新的肌醇焦磷酸合酶，并表明Vip1活性产物可调节细胞周期蛋白/细胞周期蛋白依赖性激酶复合物。
