引导配体作用于核受体。
Guiding ligands to nuclear receptors.
作者信息
Michalik Liliane, Wahli Walter
机构信息
Center for Integrative Genomics, National Research Center Frontiers in Genetics, University of Lausanne, Switzerland.
出版信息
Cell. 2007 May 18;129(4):649-51. doi: 10.1016/j.cell.2007.05.001.
Retinoic acid-the active metabolite of vitamin A-influences biological processes by activating the retinoic acid receptor (RAR). In this issue, Schug et al. (2007) demonstrate that retinoic acid also activates the peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta). Remarkably, retinoic acid signaling through RAR or PPARbeta/delta-which depends on cytoplasmic retinoic acid transporters-commits the cell to opposite fates, apoptosis or survival, respectively.
视黄酸（维生素A的活性代谢产物）通过激活视黄酸受体（RAR）影响生物学过程。在本期中，舒格等人（2007年）证明视黄酸还能激活过氧化物酶体增殖物激活受体β/δ（PPARβ/δ）。值得注意的是，视黄酸通过RAR或PPARβ/δ发出的信号（这取决于细胞质视黄酸转运蛋白）分别使细胞走向相反的命运，即凋亡或存活。
Zotero 插件