Mahmood M Asim, Zweifler Richard M
University of South Alabama Stroke Center, Suite 10-I, 2451 Fillingim Street, Mobile, AL 36617, USA.
J Neurol Sci. 2007 Oct 15;261(1-2):47-54. doi: 10.1016/j.jns.2007.04.038. Epub 2007 May 21.
Hypothermia is a potent neuroprotectant and induced hypothermia holds great promise as a therapy for acute neuronal injury. Thermoregulatory responses, most notably shivering, present major obstacles to therapeutic temperature management. A review of thermoregulatory physiology and strategies aimed at controlling physiologic responses to hypothermia is presented.
体温过低是一种有效的神经保护剂,诱导性体温过低作为急性神经元损伤的一种治疗方法具有很大的前景。体温调节反应,最显著的是寒战,是治疗性体温管理的主要障碍。本文综述了体温调节生理学以及旨在控制对体温过低的生理反应的策略。