在1.5%利多卡因用于宫颈旁阻滞时添加新斯的明和曲马多以减轻阴道修补术后疼痛。
Addition of Neostigmine and Tramadol to 1.5 % Lidocaine for paracervical block to reduce post-operative pain in colporrhaphy.
作者信息
Kamali Alireza, Shokrpour Maryam, Yazdi Bijan, Khalilpour Atefeh
机构信息
Department of Anesthesiology, Arak University of Medical Sciences, Arak, Iran.
Department of Gynecology, Arak University of Medical Sciences, Arak, Iran.
出版信息
Eur J Transl Myol. 2018 May 2;28(2):7351. doi: 10.4081/ejtm.2018.7351. eCollection 2018 Apr 24.
Pain is a complex and multi-faceted human perception and several factors could dampen the pain. Therefore, we aimed to comparison of addition of neostigmine and tramadol to 1.5 % lidocaine with paracervical block in reduce of post-operative pain in colporrhaphy. This study was a randomized and double-blind clinical trial for 108 patients' as candidate for colporrhaphy. Patients were randomly divided in three groups (Neostigmine, tramadol and control).We recorded pain in 2 and 6 and 12 hours after surgery, duration of analgesia and mean of use narcotic drug in 24 hours after surgery for all patients. Mean of narcotic drug used in 24 hours after surgery in neostigmine group was more than tramadol group(p=0/01).Pain in 2 and 6 and 12 hours after surgery in neostigmine group was more than tramadol group (p=0/01). Duration of analgesia in tramadol group was over neostigmine group and also, it was in neostigmine group was more than placebo (p=0/01).Taken together, tramadol could reduce pain in 2 and 6 and 12 hours after surgery and mean of narcotic drug used in 24 hours after surgery and increase duration of analgesia.
疼痛是一种复杂且多方面的人类感知，有多种因素可以减轻疼痛。因此，我们旨在比较在宫颈旁阻滞中添加新斯的明和曲马多至1.5%利多卡因对阴道修补术后疼痛的减轻效果。本研究是一项针对108例阴道修补术候选患者的随机双盲临床试验。患者被随机分为三组（新斯的明组、曲马多组和对照组）。我们记录了所有患者术后2小时、6小时和12小时的疼痛情况、镇痛持续时间以及术后24小时使用麻醉药物的平均值。新斯的明组术后24小时使用麻醉药物的平均值高于曲马多组（p = 0.01）。新斯的明组术后2小时、6小时和12小时的疼痛程度高于曲马多组（p = 0.01）。曲马多组的镇痛持续时间长于新斯的明组，并且新斯的明组的镇痛持续时间也长于安慰剂组（p = 0.01）。综上所述，曲马多可以减轻术后2小时、6小时和12小时的疼痛以及术后24小时使用麻醉药物的平均值，并延长镇痛持续时间。
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