Rödel Rebecca, Freyer Alexandra, Bittner Thomas, Schäfer Volker, Hunfeld Klaus-Peter
Institute of Medical Microbiology & Infection Control, University Hospital of Frankfurt, Paul-Ehrlich Str. 40, D-60596 Frankfurt/Main, Germany.
Int J Antimicrob Agents. 2007 Jul;30(1):83-6. doi: 10.1016/j.ijantimicag.2007.03.008. Epub 2007 May 18.
Little is known about the in vitro activity of penems and carbapenems against the spirochete Borrelia burgdorferi. Here, faropenem, ertapenem, imipenem and meropenem as well as the third-generation cephalosporin ceftriaxone and tobramycin were tested in vitro against 11 isolates of the B. burgdorferi sensu lato complex. On a microg/mL basis, ertapenem was the most potent carbapenem (minimal inhibitory concentration (MIC) range: 0.015-0.125 microg/mL), with in vitro activity comparable with that of ceftriaxone against Borrelia. These findings are supported by the results of time-kill experiments in a Borrelia afzelii skin isolate, demonstrating a >3 log10 unit (99.9%) reduction of the inoculum after 96 h of exposure to either drug at a concentration of three log2 unit dilutions above the respective MIC.
关于青霉烯类和碳青霉烯类药物对疏螺旋体伯氏疏螺旋体的体外活性了解甚少。在此，对法罗培南、厄他培南、亚胺培南、美罗培南以及第三代头孢菌素头孢曲松和妥布霉素进行了体外测试，以检测它们对11株广义伯氏疏螺旋体复合体菌株的活性。以微克/毫升为单位计算，厄他培南是活性最强的碳青霉烯类药物（最低抑菌浓度（MIC）范围：0.015 - 0.125微克/毫升），其体外活性与头孢曲松对伯氏疏螺旋体的活性相当。在阿氏疏螺旋体皮肤分离株上进行的时间杀菌实验结果支持了这些发现，结果表明，在高于各自MIC三个对数2倍稀释浓度的情况下，将两种药物中的任何一种与接种物接触96小时后，接种物减少了>3个对数10单位（99.9%）。
