Pihlajamäki K K
Paimio Hospital, Preitilä, Finland.
Br J Anaesth. 1991 Nov;67(5):621-2. doi: 10.1093/bja/67.5.621.
Thirty-five adult patients with rheumatoid arthritis received for 36 interscalene brachial plexus blocks a standard dose of bupivacaine 200 mg, regardless of the weight (range 39.2-102.5 kg) of the patient. The peak venous serum concentrations (Cmax) of bupivacaine, measured by HPLC, were in the range 0.82-4.30 mg litre-1; there were no signs of toxicity. There was a very significant inverse correlation between the Cmax of bupivacaine and the weight of the patient (r = -0.5922; t = -4.285; P = 0.0001, Pearson's test). In spite of the correlation, only 35.1% of the total variance could be explained by regression. Thus weight had little influence on Cmax under interscalene brachial plexus block.
35例成年类风湿性关节炎患者接受了36次肌间沟臂丛神经阻滞，无论患者体重（范围为39.2至102.5千克）如何，均给予标准剂量的200毫克布比卡因。通过高效液相色谱法测定的布比卡因静脉血清峰值浓度（Cmax）在0.82至4.30毫克/升范围内；未出现毒性迹象。布比卡因的Cmax与患者体重之间存在非常显著的负相关（r = -0.5922；t = -4.285；P = 0.0001，Pearson检验）。尽管存在相关性，但总方差中只有35.1%可由回归解释。因此，体重对肌间沟臂丛神经阻滞下的Cmax影响很小。
