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A computational model of activities performance decrease in Alzheimer's disease.

作者信息

Serna Audrey, Pigot Hélène, Rialle Vincent

机构信息

TIMC-IMAG UMR CNRS 5525 Laboratory, Grenoble, France.

出版信息

Int J Med Inform. 2007 Dec;76 Suppl 3:S377-83. doi: 10.1016/j.ijmedinf.2007.04.002. Epub 2007 May 21.

Abstract

This article presents a computational model and a simulation of the decrease of performance in daily living activities due to Alzheimer's disease. The framework offered by the cognitive architecture ACT-R is used to develop the model. Typical errors committed in performing tasks by Alzheimer patients are modelled thanks to different parametrisable memory mechanisms of ACT-R and the disease evolution is represented by the increase of errors in the execution of the task. The model is applied to a cooking activity. Simulation of 100 subjects shows results similar to those realised in a standardized assessment with human subjects. We conclude on the need to introduce executive mechanisms in the modelling of behaviours associated to people with cognitive deficits.

摘要

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