Arthur Todd M, Saneto Russell P, de Menezes Marcio Sotero, Devinsky Orrin, Lajoie Josiane, Murphy Patricia J, Cook William B, Ojemann Jeffrey G
Division of Pediatric Neurology, Children's Hospital and Regional Medical Center/University of Washington, B-5552, 4800 Sand Point Way NE, Seattle, WA 98105, USA.
Mitochondrion. 2007 Jul;7(4):279-83. doi: 10.1016/j.mito.2007.04.003. Epub 2007 Apr 25.
We retrospectively investigated outcome data for vagus nerve stimulation (VNS) in children less than 12 years of age with intractable seizures and mitochondrial disease. Five children with a mitochondrial disease, due to electron transport chain deficiency, were studied. Information was collected from clinic visits prior to, and subsequent to, VNS implantation. Data were collected by type and frequency of seizures, encephalogram and neuroimaging findings, and medication history. Four of the children had predominantly myoclonic seizures, while the other child had focal seizures with secondary generalization and myoclonic seizures. All five children did not have significant reduction in seizure frequency with VNS. VNS may not be an effective method to control myoclonic seizures in children with electron transport chain disorders.
我们回顾性研究了12岁以下患有难治性癫痫和线粒体疾病的儿童接受迷走神经刺激（VNS）的结果数据。研究了5名因电子传递链缺陷而患有线粒体疾病的儿童。收集了VNS植入前后门诊就诊的信息。数据收集内容包括癫痫发作的类型和频率、脑电图和神经影像学检查结果以及用药史。其中4名儿童主要为肌阵挛性发作，另一名儿童为局灶性发作继发全身性发作和肌阵挛性发作。所有5名儿童接受VNS治疗后癫痫发作频率均未显著降低。对于患有电子传递链疾病的儿童，VNS可能不是控制肌阵挛性发作的有效方法。
