Zhou Minhao, Martindale Robert G
Department of Surgery, Oregon Health and Science University, Portland, OR 97239, USA.
J Nutr. 2007 Jun;137(6 Suppl 2):1687S-1692S. doi: 10.1093/jn/137.6.1687S.
Arginine is a nonessential amino acid in the normal physiological state that becomes conditionally essential during periods of hypermetabolic stress. Recent literature supports the hypothesis that arginine plays an important role in the intermediary metabolism of the critically ill patient. Current critical care literature is conflicting on arginine use in the clinical setting, with some proposing it as a panacea, whereas others report it as poison. Multiple individual reports and at least 5 major meta-analyses using combinations of immune-modulating nutrients have reported mostly beneficial results, but few have evaluated the effects of arginine when given as a single supplemental nutrient. This review attempts to objectively analyze the literature and evaluate the potential role of arginine in the critical care setting.
精氨酸在正常生理状态下是非必需氨基酸，但在高代谢应激期间会成为条件必需氨基酸。最近的文献支持这样一种假说，即精氨酸在危重症患者的中间代谢中起重要作用。目前的重症监护文献对于临床环境中精氨酸的使用存在矛盾观点，一些人将其视为万灵药，而另一些人则称其为毒药。多项单独报告以及至少5项使用免疫调节营养素组合的主要荟萃分析大多报告了有益结果，但很少有研究评估精氨酸作为单一补充营养素时的效果。本综述试图客观分析文献，并评估精氨酸在重症监护环境中的潜在作用。
