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为什么要研究免疫的进化?

Why study the evolution of immunity?

作者信息

Litman Gary W, Cooper Max D

机构信息

Department of Pediatrics, University of South Florida Children's Research Institute, St. Petersburg, Florida 33701, USA.

出版信息

Nat Immunol. 2007 Jun;8(6):547-8. doi: 10.1038/ni0607-547.

Abstract

Investigations of immune recognition in nonmammalian species provide new insights into the evolution of immunity and the inner workings of the mammalian immune system. Very diverse mechanisms are used by different multicellular organisms to recognize and cope with the rapidly evolving microbial world.

摘要

对非哺乳动物物种免疫识别的研究为免疫进化和哺乳动物免疫系统的内部运作提供了新的见解。不同的多细胞生物使用非常多样的机制来识别和应对快速演变的微生物世界。

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本文引用的文献

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Adaptive immunity: care for the community.适应性免疫:守护群体。
Nature. 2007 Jan 11;445(7124):153. doi: 10.1038/445153a.
4
The evolution of adaptive immunity.适应性免疫的进化。
Annu Rev Immunol. 2006;24:497-518. doi: 10.1146/annurev.immunol.24.021605.090542.
5
An ancient evolutionary origin of the Rag1/2 gene locus.Rag1/2基因座的古老进化起源。
Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3728-33. doi: 10.1073/pnas.0509720103. Epub 2006 Feb 27.
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Reconstructing immune phylogeny: new perspectives.重建免疫系统发育史:新视角
Nat Rev Immunol. 2005 Nov;5(11):866-79. doi: 10.1038/nri1712.

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