Chung Jungrae, Jung Woonggyu, Hammer-Wilson Marie J, Wilder-Smith Petra, Chen Zhongping
Beckman Laser Institute, University of California, Irvine, California 92612, USA.
Appl Opt. 2007 May 20;46(15):3038-45. doi: 10.1364/ao.46.003038.
The Mueller matrix describes all the polarizing properties of a sample and, therefore, the optical differences between noncancerous and precancerous tissue that may be present within the matrix elements. A high-speed polarimetry system that generates 16 (4x4) full Mueller matrices to characterize tissues is presented. Feature extraction is done on the Mueller matrix elements resulting in depolarization and retardance images by polar decomposition. These are used to detect and classify early oral cancers and precancerous changes in epithelium such as dysplasia. These images are compared with orthogonal polarization images and analyzed in an attempt to identity useful factors for the differentiation between cancerous lesions and their benign counterparts. Our results indicate that polarimetry has potential as a method for the in vivo early detection and diagnosis of oral premalignancy.
穆勒矩阵描述了样品的所有偏振特性，因此也描述了可能存在于矩阵元素中的非癌组织和癌前组织之间的光学差异。本文介绍了一种高速偏振测量系统，该系统可生成16个（4x4）完整的穆勒矩阵来表征组织。通过对穆勒矩阵元素进行特征提取，利用偏振分解得到去极化和延迟图像。这些图像用于检测和分类早期口腔癌以及上皮组织中的癌前变化，如发育异常。将这些图像与正交偏振图像进行比较并分析，试图找出区分癌性病变与其良性对应物的有用因素。我们的结果表明，偏振测量法有潜力作为一种体内早期检测和诊断口腔癌前病变的方法。
