Kluftinger A M, Davis N L, Quenville N F, Lam S, Hung J, Palcic B
Department of Surgery, Vancouver General Hospital, British Columbia, Canada.
Surg Oncol. 1992 Apr;1(2):183-8. doi: 10.1016/0960-7404(92)90032-g.
Early detection of invasive and pre-invasive neoplasms of the aerodigestive tract will ultimately improve the management of patients with these lesions. This paper describes the use of quantitative fluorescence imaging of early squamous cell carcinomas in an animal model. Dysplasia, carcinoma in situ and invasive cancers were imaged exploiting tumour autofluorescence. Mapped biopsies were obtained from areas imaged determining a sensitivity of 100% and specificity of 80%. Autofluorescence imaging is an excellent method of detecting neoplasms of the aerodigestive tract.
早期发现气道消化道的浸润性和癌前肿瘤最终将改善这些病变患者的治疗。本文描述了在动物模型中对早期鳞状细胞癌进行定量荧光成像的应用。利用肿瘤自身荧光对发育异常、原位癌和浸润性癌进行成像。从成像区域获取映射活检样本，确定其灵敏度为100%，特异性为80%。自身荧光成像是检测气道消化道肿瘤的一种优秀方法。
