Peel K R, Khoury G G, Joslin C A, O'Donovan P J, Mgaya H, Keates G, Head C, Thorogood D J
Department of Gynaecology, General Infirmary, Leeds.
Br J Obstet Gynaecol. 1991 Oct;98(10):993-1000. doi: 10.1111/j.1471-0528.1991.tb15337.x.
To review the method and results of treatment of carcinoma of the cervix in women less than 40 years old.
Retrospective review of all available case records.
Yorkshire Regional Health Authority.
428 women less than 40 years old treated for stage IB-IV carcinoma of the cervix between 1975 and 1984 inclusive.
Overall survival by stage, effect of age, identifiable factors of prognostic significance, survival, grade 3 morbidity and pattern of recurrence in relation to treatment.
The 5-year actuarial percentage survival by stage was 78.4 (IB), 54.4 (II), 18.4 (III) and 0 (IV). Identifiable factors of prognostic importance were stage, nodal metastases (P less than 0.001) and tumour grade (P less than 0.01).
Primary surgical treatment for young women with early disease allows ovarian conservation and the avoidance of radiotherapy in 80% of them. Such treatment results in less local recurrence, particularly evident in patients with moderate or poorly differentiated tumours and a lower incidence of serious morbidity.
回顾40岁以下女性宫颈癌的治疗方法及结果。
对所有可用病例记录进行回顾性分析。
约克郡地区卫生局。
1975年至1984年（含）期间接受治疗的428例40岁以下宫颈癌I B-IV期女性患者。
各期总体生存率、年龄的影响、具有预后意义的可识别因素、生存率、3级发病率以及与治疗相关的复发模式。
各期5年精算生存率分别为78.4%（I B期）、54.4%（II期）、18.4%（III期）和0%（IV期）。具有预后重要性的可识别因素为分期、淋巴结转移（P<0.001）和肿瘤分级（P<0.01）。
对早期疾病的年轻女性进行原发手术治疗可保留卵巢，80%的患者可避免放疗。这种治疗导致局部复发较少，在中分化或低分化肿瘤患者中尤为明显，严重发病率较低。
