Lentz Martha J, Woods Nancy, Heitkemper Margaret, Mitchell Ellen, Henker Richard, Shaver Joan
Office of the Dean, School of Nursing, University of Washington, Box 357262, Seattle, WA, USA.
Res Nurs Health. 2007 Jun;30(3):238-49. doi: 10.1002/nur.20188.
To examine the relationship of gonadal hormone and symptom patterns across the menstrual cycle, women screened for 2-3 cycles completed an intensive study cycle; 26 had a low-severity symptoms (LS), 20, a premenstrual syndrome (PMS), and 26, a premenstrual magnification pattern (PMM). All completed daily symptom diaries and collected late afternoon urine samples which were assayed for pregnanediol and estradiol for that cycle. The PMS and PMM groups had significantly more positive cross-correlations of pregnanediol and symptoms than the LS group. Women in all groups had similar levels of estradiol and pregnanediol. Women with PMS and PMM patterns responded to progesterone differently than women with LS patterns: thus the former groups may not benefit from hormone therapies.
为了研究性腺激素与整个月经周期症状模式之间的关系，筛选出经历2 - 3个周期的女性完成一个强化研究周期；其中26人有低严重程度症状（LS），20人有经前综合征（PMS），26人有经前放大模式（PMM）。所有人都完成了每日症状日记，并收集了傍晚时分的尿液样本，对该周期的孕二醇和雌二醇进行检测。PMS组和PMM组孕二醇与症状的正交叉相关性显著高于LS组。所有组的女性雌二醇和孕二醇水平相似。有PMS和PMM模式的女性对孕酮的反应与有LS模式的女性不同：因此前两组可能无法从激素疗法中获益。
