Woods N F, Lentz M J, Mitchell E S, Shaver J, Heitkemper M
Center for Women's Health Research, University of Washington, Seattle 98195, USA.
Res Nurs Health. 1998 Apr;21(2):129-42. doi: 10.1002/(sici)1098-240x(199804)21:2<129::aid-nur4>3.0.co;2-l.
The purpose of this study was to examine the relationships among perceived stress, ovarian steroids (estradiol and pregnanediol), stress arousal indicators (cortisol, catecholamines) and premenstrual symptoms (turmoil, fluid retention). Women (N = 74) with low symptom severity (LS), premenstrual syndrome (PMS), or premenstrual magnification (PMM) symptom patterns provided daily urine samples over one cycle and recorded their symptoms and perceived stress levels in a health diary. Multiple regression analysis was used to test models of premenstrual symptoms in separate analyses for women with the LS and PMS symptom patterns and the LS and PMM symptom patterns. Data from the LS and PMS groups revealed that greater stress ratings accounted for turmoil symptoms and higher luteal phase cortisol levels for fluid retention symptoms. For LS and PMM groups, lower luteal phase norepinephrine levels, higher global stress ratings, and a more gradual drop in estradiol premenses accounted for turmoil symptoms. Premenses norepinephrine and epinephrine levels and premenses stress ratings accounted for fluid retention. These findings support an important relationship among perceived stress, stress arousal indicators, and premenstrual symptoms that differs for women with a PMS and PMM symptom pattern.
本研究的目的是检验感知压力、卵巢类固醇（雌二醇和孕二醇）、应激唤醒指标（皮质醇、儿茶酚胺）与经前症状（情绪紊乱、液体潴留）之间的关系。症状严重程度低（LS）、经前综合征（PMS）或经前放大（PMM）症状模式的女性（N = 74）在一个周期内每天提供尿液样本，并在健康日记中记录她们的症状和感知压力水平。在对具有LS和PMS症状模式以及LS和PMM症状模式的女性进行的单独分析中，使用多元回归分析来检验经前症状模型。来自LS和PMS组的数据显示，更高的压力评分可解释情绪紊乱症状，而更高的黄体期皮质醇水平可解释液体潴留症状。对于LS和PMM组，更低的黄体期去甲肾上腺素水平、更高的总体压力评分以及经前雌二醇水平更缓慢的下降可解释情绪紊乱症状。经前去甲肾上腺素和肾上腺素水平以及经前压力评分可解释液体潴留。这些发现支持了感知压力、应激唤醒指标和经前症状之间的重要关系，这种关系在患有PMS和PMM症状模式的女性中有所不同。
