1,4-苯二氮䓬-2-酮的选定衍生物在聚乙二醇6000固体分散体中的溶解度。

Solubility of selected derivatives of 1,4-benzodiazepin-2-one in solid dispersions in PEG 6000.

作者信息

Cwiertnia Barbara

机构信息

Poznań University of Medical Sciences, Department of Inorganic and Analytical Chemistry 6 Grunwaldzka Street, 60-780 Poznań, Poland.

出版信息

Acta Pol Pharm. 2006 Mar-Apr;63(2):135-9.

PMID:17514877

Abstract

Pharmaceutical availability of diazepam, oxazepam and nitrazepam from solid dispersions of PEG 6000 have been studied in comparison with corresponding physical mixtures and pure benzodiazepines. Selected derivatives of 1,4-benzodiazepin-2-one are poorly water soluble drugs. The aim of this work was to report the properties of diazepam- and nitrazepam-PEG 6000 solid dispersions. Differential scanning calorimetry (DSC) and X-ray diffraction were used to characterize the solid dispersions. The effect of PEG 6000 on the dissolution of selected derivatives of 1,4-benzodiazepin-2-one was investigated. The dissolution of diazepam, oxazepam and nitrazepam from its solid dispersions increased in the presence of PEG 6000.

摘要

已对聚乙二醇6000（PEG 6000）固体分散体中地西泮、奥沙西泮和硝西泮的药物可利用性进行了研究，并与相应的物理混合物和纯苯二氮䓬类药物进行了比较。1,4-苯二氮䓬-2-酮的选定衍生物是水溶性较差的药物。这项工作的目的是报告地西泮-PEG 6000和硝西泮-PEG 6000固体分散体的性质。采用差示扫描量热法（DSC）和X射线衍射对固体分散体进行表征。研究了PEG 6000对1,4-苯二氮䓬-2-酮选定衍生物溶解的影响。在PEG 6000存在下，地西泮、奥沙西泮和硝西泮从其固体分散体中的溶出度增加。