5-芳亚甲基-2,4-二氧代噻唑烷-3-乙酸与1,2,4-三唑体系的酰胺的合成
Synthesis of amides of 5-arylidene-2,4-dioxothiazolidine-3-acetic acid with 1,2,4-triazole system.
作者信息
Trotsko Nazar, Dobosz Maria, Lukianchuk Victor
机构信息
Department of Organic Chemistry, Faculty of Pharmacy, Lublin Medical University, 6 Staszica Str., 20-081 Lublin, Poland.
出版信息
Acta Pol Pharm. 2006 Jan-Feb;63(1):47-52.
PMID:17515329
Abstract
In the reaction of 5-arylidene-2,4-dioxothiazolidine-3-acetic acid chloride with 1,2,4-triazole, 1,2,4-triazoline-5-one and 1,2,4-triazoline-5-thione, the new corresponding 5-arylidene-2,4-dioxothiazolidine-3-acetic acid amides (5-16) were obtained. Compounds 6, 14 i 15 were investigated in vitro for their antioxidant activity.
摘要
在5-亚芳基-2,4-二氧代噻唑烷-3-乙酰氯与1,2,4-三唑、1,2,4-三唑啉-5-酮和1,2,4-三唑啉-5-硫酮的反应中，得到了新的相应的5-亚芳基-2,4-二氧代噻唑烷-3-乙酰胺（5-16）。对化合物6、14和15进行了体外抗氧化活性研究。
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