Search for substances with antioxidant and antiamnestic activities among 2-substituted 4-(3H)-quinazolones.

We have synthesised some of 2-substituted 4-(3H)-quinazolones by the reaction with benzaldehyde and cinnamic aldehyde and their derivatives. It is shown that the intensity of the reaction depends on electrophilic properties of carbonyl compounds and steric factors. The elemental analysis, ultraviolet (UV), infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy confirmed the structure of synthesised compounds, their individuality being checked by thin-layer chromatography. The results of biological experiments show that the synthesised 2-substituted 4-(3H)-quinazolones have an expressed antioxidant and antiamnestic activity and are prospective for further research of their nootropic activity.