Santini M T, Indovina P L, Cantafora A
Laboratorio di Ultrastrutture, Istituto Superiore di Sanità, Roma, Italy.
Biochim Biophys Acta. 1991 Nov 18;1070(1):27-32. doi: 10.1016/0005-2736(91)90142-u.
We have recently demonstrated that the delay in myoblast membrane fusion induced by cesium is accompanied by changes in isolated membrane lipids (Santini, M.T., Indovina, P.L., Cantafora, A. and Blotta, I. (1990) Biochim. Biophys. Acta 1023, 298-304). In the present study, we have investigated changes in the lipid profile of total cell homogenates and microsomal membrane fractions during myoblast membrane fusion as well as the effects that addition of cesium may have on these lipid variations in order to try to understand the production and translocation of lipids during this myogenic process. The data presented here indicate that the lipid composition of cell homogenates and microsomes varies in a different manner from isolated plasma membranes during myogenic fusion. In addition, cesium affects, in a different manner, the normally-occurring lipid production and distribution which takes place in each subcellular fraction.
我们最近证明，铯诱导的成肌细胞膜融合延迟伴随着分离膜脂的变化（桑蒂尼，M.T.，因多维纳，P.L.，坎塔福拉，A.和布洛塔，I.（1990年）《生物化学与生物物理学报》1023卷，298 - 304页）。在本研究中，我们研究了成肌细胞膜融合过程中全细胞匀浆和微粒体膜组分的脂质谱变化，以及添加铯可能对这些脂质变化产生的影响，以便试图了解在此生肌过程中脂质的产生和转运。此处呈现的数据表明，在生肌融合过程中，细胞匀浆和微粒体的脂质组成与分离的质膜以不同方式变化。此外，铯以不同方式影响每个亚细胞组分中正常发生的脂质产生和分布。
