Sacerdote Carlotta, Matullo Giuseppe, Polidoro Silvia, Gamberini Sara, Piazza Alberto, Karagas Margaret R, Rolle Luigi, De Stefanis Paolo, Casetta Giovanni, Morabito Francesco, Vineis Paolo, Guarrera Simonetta
Unità di Epidemiologia dei Tumori, Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino and CPO-Piemonte, Torino, Italy.
Mutagenesis. 2007 Jul;22(4):281-5. doi: 10.1093/mutage/gem014. Epub 2007 May 21.
The objective is to investigate the relationships between fruit and vegetable intake, DNA repair gene polymorphisms and the risk of bladder cancer. We have analyzed a hospital-based case-control study of 266 individuals with incident, histologically confirmed bladder cancer diagnosed between 1994 and 2003. Controls (n = 193) were patients treated for benign diseases recruited daily in a random fashion from the same hospital as the cases. All cases and controls were interviewed face-to-face for major risk factors, along fruit and vegetable consumption. Odds ratios (ORs) for fruit and vegetable intake and DNA repair gene polymorphisms were adjusted for age and smoking status, using unconditional logistic regression. A statistically significant decreased risk was observed for fruit and vegetable intake above median (versus below the median) [unadjusted OR 0.61, confidence interval (CI) 95% 0.50-0.96 and OR 0.54, CI 95% 0.39-0.80, respectively]; the decreased risk persisted after adjustment for age and cigarette smoking (OR 0.73, CI 95% 0.49-1.01 and OR 0.86, CI 95% 0.56-1.08, respectively). The fruits and vegetables associated with decreased risks included leafy green vegetables, cruciferous vegetables, apples and citrus fruits. We did not find any interactions between DNA repair gene polymorphisms and fruit and vegetable intake. This study found a reduced risk associated with fruit and vegetable intake. No interaction was observed between fruit and vegetable consumption and DNA repair gene polymorphisms.
目的是研究水果和蔬菜摄入量、DNA修复基因多态性与膀胱癌风险之间的关系。我们分析了一项基于医院的病例对照研究，该研究纳入了1994年至2003年间确诊的266例新发、经组织学证实的膀胱癌患者。对照组（n = 193）是从与病例相同的医院中随机招募的患有良性疾病的患者。所有病例和对照均就主要危险因素，包括水果和蔬菜的消费情况，进行了面对面访谈。使用无条件逻辑回归对水果和蔬菜摄入量以及DNA修复基因多态性的比值比（OR）进行年龄和吸烟状况调整。观察到水果和蔬菜摄入量高于中位数（相对于低于中位数）时风险显著降低[未调整的OR分别为0.61，95%置信区间（CI）0.50 - 0.96和OR 0.54，CI 95% 0.39 - 0.80]；在对年龄和吸烟进行调整后，风险降低仍然存在（OR分别为0.73，CI 95% 0.49 - 1.01和OR 0.86，CI 95% 0.56 - 1.08）。与风险降低相关的水果和蔬菜包括绿叶蔬菜、十字花科蔬菜、苹果和柑橘类水果。我们未发现DNA修复基因多态性与水果和蔬菜摄入量之间存在任何相互作用。本研究发现水果和蔬菜摄入量与风险降低相关。未观察到水果和蔬菜消费与DNA修复基因多态性之间存在相互作用。
