Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-136 Lodz, Poland.
Biohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-136 Lodz, Poland.
Int J Mol Sci. 2021 Jul 21;22(15):7787. doi: 10.3390/ijms22157787.
Bladder cancer (BC) is the second most common genitourinary cancer. In 2018, 550,000 people in the world were diagnosed with BC, and the number of new cases continues to rise. BC is also characterized by high recurrence risk, despite therapies. Although in the last few years, the range of BC therapy has considerably widened, it is associated with severe side effects and the development of drug resistance, which is hampering treatment success. Thus, patients are increasingly choosing products of natural origin as an alternative or complementary therapeutic options. Therefore, in this article, we aim to elucidate, using the available literature, the role of natural substances such as curcumin, sulforaphane, resveratrol, quercetin, 6-gingerol, delphinidin, epigallocatechin-3-gallate and gossypol in the BC treatment. Numerous clinical and preclinical studies point to their role in the modulation of the signaling pathways, such as cell proliferation, cell survival, apoptosis and cell death.
膀胱癌（BC）是第二大常见的泌尿生殖系统癌症。2018 年，全球有 55 万人被诊断出患有 BC，且新发病例数量仍在持续上升。BC 的特点还包括高复发风险，尽管有多种治疗方法。尽管在过去几年中，BC 的治疗范围已经大大扩大，但它与严重的副作用和耐药性的发展有关，这阻碍了治疗的成功。因此，患者越来越多地选择天然产物作为替代或补充治疗选择。因此，在本文中，我们旨在利用现有文献阐明姜黄素、萝卜硫素、白藜芦醇、槲皮素、6-姜酚、飞燕草素、表没食子儿茶素没食子酸酯和棉酚等天然物质在 BC 治疗中的作用。许多临床和临床前研究表明它们在调节信号通路中的作用，如细胞增殖、细胞存活、细胞凋亡和细胞死亡。
