Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-136 Lodz, Poland.
Biohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-136 Lodz, Poland.
Nutrients. 2022 Mar 8;14(6):1132. doi: 10.3390/nu14061132.
Bladder cancer (BC) is the most common tumor of the urinary system in the world. Moreover, despite using anticancer therapies, BC is also characterized by a high recurrence risk. Among numerous risk factors, cigarette smoking, occupational exposure to certain aromatic compounds, and genetic factors contribute most strongly to BC development. However, the epidemiological data to date suggests that diet quality may influence some carcinogenic factors of BC and, therefore, might have a preventative effect. Adequate consumption of selected fruits with scientifically proven properties, including pomegranates and cranberries, can significantly reduce the risk of developing BC, even in those at risk. Therefore, in this article, we aim to elucidate, using available literature, the role of fruits, including pomegranates, cranberries, citrus fruits, cactus pears, and apples, in BC prevention and treatment. Previous data indicate the role of compounds in the above-mentioned fruits in the modulation of the signaling pathways, including cell proliferation, cell growth, cell survival, and cell death.
膀胱癌（BC）是世界上最常见的泌尿系统肿瘤。此外，尽管使用了抗癌疗法，BC 也具有很高的复发风险。在众多危险因素中，吸烟、职业性接触某些芳香族化合物和遗传因素对 BC 的发展贡献最大。然而，迄今为止的流行病学数据表明，饮食质量可能会影响 BC 的一些致癌因素，因此可能具有预防作用。适量食用具有科学证明的特性的某些水果，包括石榴和蔓越莓，可以显著降低患 BC 的风险，即使是那些有风险的人也不例外。因此，在本文中，我们旨在利用现有文献阐明水果（包括石榴、蔓越莓、柑橘类水果、仙人掌果和苹果）在 BC 的预防和治疗中的作用。先前的数据表明，上述水果中的化合物在调节信号通路方面发挥作用，包括细胞增殖、细胞生长、细胞存活和细胞死亡。
